2014年6月19日（周四）上午10:30，物理系seminar：

報告題目： Detecting Protein Dynamics in Various Time Scales by Neutron Scattering 報告人： Xiang-qiang Chu Department of Physics and Astronomy, Wayne State University 報告時間： 2014-6-19 10:30 報告地點：理科樓三樓報告廳摘要： Proteins undergo sophisticated changes in space and time, in order to keep the cells functioning. These motions are believed to ultimately govern the biological function and activities of the protein. Various tools are used to study the protein dynamics, such as NMR spectroscopy, Raman spectroscopy and Infrared spectroscopy. Among these, neutron scattering provide exceptional tools for studying the structures and dynamics of protein in real time at the molecular level. In our recent research, quasi-elastic neutron scattering (QENS) experiments were carried out to study the protein dynamics by using a “state-of-the-art” backscattering spectrometer at the world’s largest neutron source at Oak Ridge National Lab (ORNL). As a result, an exotic logarithmic decay in the relaxational dynamics of proteins is observed in the time range of 10ps to 1ns. This is the first experimental observation of logarithmic behavior in protein relaxation. In addition, using a direct time-of-flight Fermi chopper neutron spectrometer (SEQUOIA) at ORNL, we obtained a full map of the milli-eV phonon-like excitations in the fully deuterated protein. The Q range of the observed excitations corresponds to the length scale of about 2.5 to 3 Å, which is close to the length scales of the secondary structures of proteins (4-5 Å) and reflects the collective intra-protein motions. These observations and further investigation using neutron scattering can reveal important macromolecular behavior that cannot be otherwise measured by other techniques. 個人簡曆： Dr. Xiang-qiang Chu received her B.S. and M.S. degrees in Physics from Peking University (China), and Ph.D. degree in Nuclear Science and Engineering from Massachusetts Institute of Technology (MIT) in June 2010. After two years of postdoctoral research at Oak Ridge National Laboratory (ORNL), she joined Department of Physics and Astronomy at Wayne State University as an Assistant Professor in August 2012. Her research interests focus on probing the structure and dynamics of biomolecules, nano-materials and their hydration water or surface water through neutron and X-ray scattering spectroscopy and computational simulations.